| Rank | Name | Pos | Team | Salary Diff |
| 1 | Brandon Webb | P | AZ | $-36 |
| 2 | Cole Hamels | P | PHI | $-28 |
| 3 | Geovany Soto | C | CHC | $-27 |
| 4 | Jose Reyes | SS | NYM | $-26 |
| 5 | Josh Hamilton | OF | TEX | $-25 |
| 6 | Jake Peavy | P | CHW | $-24 |
| 7 | Kelly Johnson | 2B | AZ | $-23 |
| 8 | Johan Santana | P | NYM | $-23 |
| 9 | Mike Aviles | SS | KC | $-23 |
| 10 | Cameron Maybin | OF | FLA | $-22 |
| 11 | Roy Oswalt | P | HOU | $-22 |
| 12 | Brad Lidge | P | PHI | $-21 |
| 13 | Jhonny Peralta | 3B/SS | CLE | $-21 |
| 14 | Garrett Atkins | 3B/1B | BAL | $-20 |
| 15 | Carlos Delgado | 1B | FA | $-20 |
| 16 | Vladimir Guerrero | DH | TEX | $-20 |
| 17 | Lastings Milledge | OF | PIT | $-20 |
| 18 | Manny Ramirez | OF | LAD | $-20 |
| 19 | Scott Kazmir | P | LAA | $-19 |
| 20 | Daisuke Matsuzaka | P | BOS | $-19 |
| 21 | David Ortiz | DH | BOS | $-19 |
| 22 | B.J. Ryan | P | CHC | $-19 |
| 23 | Carlos Gomez | OF | MIL | $-18 |
| 24 | Joba Chamberlain | P | NYY | $-18 |
| 25 | Alexi Casilla | 2B | MIN | $-17 |
| 26 | Derek Lowe | P | ATL | $-17 |
| 27 | Aubrey Huff | 1B/DH | SF | $-17 |
| 28 | Carlos Beltran | OF | NYM | $-17 |
| 29 | Xavier Nady | OF | CHC | $-17 |
| 30 | Francisco Rodriguez | P | NYM | $-17 |
| 31 | Jim Thome | DH | MIN | $-16 |
| 32 | Carlos Marmol | P | CHC | $-16 |
| 33 | David Wright | 3B | NYM | $-16 |
| 34 | Matt Capps | P | WSH | $-16 |
| 35 | Francisco Liriano | P | MIN | $-16 |
| 36 | Conor Jackson | OF | AZ | $-16 |
| 37 | Edinson Volquez | P | CIN | $-15 |
| 38 | Alex Gordon | 3B | KC | $-15 |
| 39 | Chad Billingsley | P | LAD | $-15 |
| 40 | Chris Young | OF | AZ | $-15 |
| 41 | Pat Burrell | DH | TB | $-15 |
| 42 | Alfonso Soriano | OF | CHC | $-15 |
| 43 | Adrian Beltre | 3B | BOS | $-14 |
| 44 | Aramis Ramirez | 3B | CHC | $-14 |
| 45 | Melvin Mora | 3B | COL | $-13 |
| 46 | C.C. Sabathia | P | NYY | $-13 |
| 47 | Matt Lindstrom | P | HOU | $-13 |
| 48 | Chris Young | P | SD | $-13 |
| 49 | Grady Sizemore | OF | CLE | $-13 |
| 50 | Chris Davis | 1B | TEX | $-13 |